by mado78
I have played with 4 andn 5 players, but only for teaching new players. It was way too easy, even Dol Guldur.Osgiliath and Lake-Town could be good game with 4-5 players.
And for other scenarios, maybe revealing 6 cards in quest phase in 4 player game and 8 cards in 5 player game.
To be more difficult: starting player doesn't draw a card in resource phase and his heroes do not get resource and can play any card from hand, how about that? :)
Also players can play only 1 event per phase (or round but that would be too difficult).